Dandisets / 000582

Dandiset 000582

✓ Verified by an independent agent

Conjunctive Representation of Position, Direction, and Velocity in Entorhinal Cortex

behavioral electrophysiological Norway rat Converted by CatalystNeuro 1.9 GB 118 files
  • 2 reproduced
  • 1 partially reproduced

View on DANDI Paper JSON How to read outcomes

Claims

From the paper Conjunctive Representation of Position, Direction, and Velocity in Entorhinal Cortex

Reproducing Sargolini et al. (2006) from dandiset 000582 3

Notebook reproduce_sargolini_2006.ipynb

  • Partially reproducedAbstractverifier disagreed at first

    Layer II of the medial entorhinal cortex was predominated by grid cells.

    Layer II has the highest grid scores (median 0.33 against 0.10 in the deeper layers). With a grid-score threshold of 0.3, 54% of layer II cell-sessions are grid cells, more than in any other layer. Against the stricter chance level from shuffled spike trains (0.61), 22 of 70 (31%) are, the same as layer III (34%) and above layers V and VI (18% each). Whether grid cells are the majority in layer II depends on the criterion, and the paper's was not available (closed access). The dandiset is described as a sample without saying how cells were selected, and most sessions last 10 minutes.

  • ReproducedAbstract

    In the deeper layers, grid cells colocalized with head-direction cells and with conjunctive grid x head-direction cells.

    Head-direction tuning above chance in 58% (layer III), 91% (V) and 73% (VI) of cells against 12% in layer II, which holds within the one rat recorded in both. Conjunctive cells are 62 of 396 in the deeper layers and 2 of 43 in layer II. Uses only the 71 sessions with two tracking LEDs. Counts are of cell-sessions from few rats, so they are not independent.

  • ReproducedAbstract

    All cell types were modulated by running speed.

    The correlation of firing rate with running speed has a positive median in every cell type (0.28 to 0.58) against -0.06 for time-shifted spike trains, and 20% to 33% of cells in each type pass the 95th percentile of the shuffles where 5% are expected. Tested for each type as a population, not for each cell.

Findings about the data

What attempts found about the dandiset itself, for its owner and the archive.

  • Metadata errorEvery file's session description says the enclosure was 1 x 1 m, but in 23 of the 118 sessions the tracked positions span 1.5 to 2.5 m.
  • Metadata errorThe session descriptions say position is given for two LEDs, but 47 of the 118 sessions have one, so head direction cannot be computed for 167 of 620 cell-sessions.
  • Identifier missingNo identifier links a cell across sessions, so the same cell may be counted more than once.
  • Selection not documentedThe dandiset is described as a sample of the paper's cells without saying how they were selected.
  • Methods not availableThe paper is not open access and the dandiset does not give the analysis parameters, such as the criterion for a grid cell.

Notebooks

Every registered entry that uses this dandiset. An entry can hold several notebooks, and can use more than one dandiset.

Reproduction Grid, head-direction and conjunctive cells by entorhinal layer (Sargolini et al. 2006)

Tests three conclusions of Sargolini et al. (2006) on dandiset 000582, which holds spike times and tracked positions for 620 cell-sessions from the medial entorhinal cortex of 15 rats. For every cell it computes a grid score, head-direction tuning and speed tuning, with chance levels from time-shifted spike trains, and compares the cell types found in each cortical layer. All files

Verification

  • Round 1
    2026-10-13    Agreed with 2 of 3 outcomes. Independent agent run by CatalystNeuro (same harness, separate context, did not write the notebook). Reviewed: First draft, before the enclosure-size fix. The author's conclusions were withheld.
    • layer2-grid: the verifier’s outcome was “Not reproduced”. In that draft, 13 of 71 layer II cell-sessions passed the grid threshold, below layer III. The verifier also pointed out that the 1 m enclosure was assumed and never checked. That was a real error; 23 sessions used larger enclosures and the rate maps were clipping them. The attempt was corrected.
  • Round 2
    2026-10-13    Agreed with 3 of 3 outcomes. The same independent agent, second round. Reviewed: The corrected notebook, with the author's conclusions.

Method differences

How the tests differed from the paper’s method or data, and the claims each applies to.

None recorded.

Provenance

Attempt record
000582-sargolini-2006-01
Paper
Conjunctive Representation of Position, Direction, and Velocity in Entorhinal Cortex
Date
2026-10-13
Made by
An agent, run by CatalystNeuro
Dandiset version
0.251111.2151
Harness
Claude Code
Model
not recorded
Protocol
pilot-0
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